Guoan Zheng

Associate Professor

Department of Biomedical Engineering

---

Education

• B.S., Zhejiang University M.S., California Institute of Technology
• Ph.D.,California Institute of Technology

Research Summary

The research of the Smart Imaging Laboratory is focused on the development of novel imaging/sensing tools to tackle measurement problems in biology, medicine, and metrology. The major techniques that are under development include gigapixel microscopy platforms, super-resolution florescence imaging approaches, 3D tomography imaging, ePetri dish and related lab-on-a-chip platforms, surface-plasmon-enabled imaging devices, and other novel imaging techniques. In particular, the Fourier Ptychography approach developed by our group represents a new way of tackling microscopy by transforming a physical optical problem to a computational problem. Through this reduction, we can push the performance of standard imaging systems beyond their physical limitations. We have demonstrated the use of Fourier ptychography for high-resolution gigapixel imaging, quantitative phase imaging, spectral multiplexing, adaptive imaging, super-resolution fluorescence imaging, 3D holographic imaging, incoherent photographic imaging, and remote sensing. More information about current projects can be found at: Smart imaging lab at UConn: https://sites.google.com/view/smartimaging/home/

Awards and Honors

• Caltech Demetriades Thesis Prize, 2013
• Phi-Tau-Phi Scholarship, Phi-Tau-Phi Scholastic Honor Society, 2012
• Lemelson-MIT Caltech Student Prize, Kirsch Auditorium, MIT Stata Center, 2011

Publications

Pengming Song, Ruihai Wang, Lars Loetgering, Jia Liu, Peter Vouras, Yujin Lee, Shaowei Jiang, Bin Feng, Andrew Maiden, Changhuei Yang, Guoan Zheng, “Ptycho-endoscopy on a lensless ultrathin fiber bundle tip,” Light: Science and Applications, 13, 168, (2024)

Tiantian Guo, Jia Liu, Longtu Chen, Zichao Bian, Guoan Zheng, Bin Feng,  “Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization,” American Journal of Physiology, 2, G133-G146 (2024) 

(Invited) Ruihai Wang, Liming Yang, Yujin Lee, Kevin Sun, Kuangyu Shen, Qianhao Zhao, Tianbo Wang, Xincheng Zhang, Jiayi Liu, Pengming Song, Guoan Zheng, “Spatially-coded Fourier ptychography flexible and detachable coded thin films for quantitative phase imaging with uniform phase transfer characteristics“, Advanced Optical Materials, 2303028, (2024).

Lucas Kreiss, Shaowei Jiang, Xiang Li, Shiqi Xu, Kevin C. Zhou, Kyung Chul Lee, Alexander Mühlberg, Kanghyun Kim, Amey Chaware, Michael Ando, Laura Barisoni, Seung Ah Lee, Guoan Zheng, Kyle J. Lafata, Oliver Friedrich & Roarke Horstmeyer, “Digital staining in optical microscopy using deep learning – a review“, PhotoniX (4), 34 (2023).  

(Selected as ‘Spotlight on Optics‘) Liming Yang, Ruihai Wang, Qianhao Zhao, Pengming Song, Shaowei Jiang, Tianbo Wang, Xiaopeng Shao, Chengfei Guo, Rishikesh Pandey, and Guoan Zheng, “Lensless polarimetric coded ptychography for high-resolution, high-throughput gigapxiel birefringence imaging on a chip,” Photonics Research, 11(12), 2242-2255 (2023).

Fangyuan Liu, Xingxu Lu, Chunxiang Zhu, Zichao Bian, Xiaohui Song, Jiyu Sun, Bo Zhang, Junfei Weng, Ashwanth Subramanian, Xiao Tong, Lichun Zhang, Avinash Dongare, Chang-Yong Nam, Yong Ding, Guoan Zheng, Haiyan Tan, and Pu-Xian Gao, “Unraveling Anisotropic and Pulsating Etching of ZnO Nanorods in Hydrochloric Acid via Correlative Electron Microscopy,” ACS Nano, 17(13), 12603-12615 (2023).

Shaowei Jiang, Pengming Song, Tianbo Wang, Liming Yang, Ruihai Wang, Chengfei Guo, Bin Feng, Andrew Maiden, and Guoan Zheng, “Spatial and Fourier domain ptychography for high-throughput bio-imaging,” Nature Protocols, 18, 2051-2083 (2023).

Shaoting Qi, Zilin Deng, Pan Qi, Jun Liao, Zibang Zhang, Guoan Zheng, and Jingang Zhong, “Image-free active autofocusing with dual modulation and its application to Fourier single-pixel imaging,” Optics Letter, 48(7), (2023).

Chengfei Guo, ShaoweiJiang, Liming Yang, Pengming Song, Azady Pirhanov, Ruihai Wang, Tianbo Wang, Xiaopeng Shao, Qian Wu, Yong Ku Cho, Guoan Zheng, “Depth-multiplexed ptychographic microscopy for high-throughput imaging of stacked bio-specimens on a chip,”  Biosensors and Bioelectronics, 224,115049 (2023).

(Selected as Lab on a Chip Hot Articles 2023) Dichson M.D. Siu, Dickson M. D. Siu, Kelvin C. M. Lee, Bob M. F. Chung,  Justin S. J. Wong,  Guoan Zheng and  Kevin K. Tsia, “Optofluidic imaging meets deep learning: from merging to emerging,” Lab on a Chip, (2023).

Pengming Song, Tianbo Wang, Shaowei Jiang, Chengfei Guo,  Ruihai Wang, Liming Yang, You Zhou, and Guoan Zheng, “Freeform illuminator for computational microscopy,” Intelligent Computing, 2, 0015, (2023). 

Tianbo Wang, Shaowei Jiang, Pengming Song, Ruihai Wang, Liming Yang, Terrance Zhang, and Guoan Zheng, “Optical ptychography for biomedical imaging: recent progress and future directions [Invited]“, Biomedical Optics Express, 14(2), 489-532, (2023).

Tianbo Wang, Pengming Song, Shaowei Jiang, Ruihai Wang, Liming Yang, Chengfei Guo, Zibang Zhang, and Guoan Zheng, “Remote referencing strategy for high-resolution coded ptychographic imaging,” Optics Letter, 48(2), 485-488, (2023).