Robin Bogner

Director, Kildsig Center for Pharmaceutical Processing Research (CPPR)

Professor of Pharmaceutics

Department of Pharmaceutical Sciences

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Education

• Ph.D. Rutgers University, Pharmaceutics
• M.S. University of Iowa, Pharmaceutics
• B.S. Rutgers University, Pharmacy

Research Focus

• Freeze-Drying/Lyophilization of pharmaceuticals
• Stabilization of protein therapeutics and emerging therapies
• Dissolution enhancement of drug solubility

Awards

• NIPTE Michael J. Pikal Distinguished Scholar Award in Pharmaceutical Processing, 2018
• Fellow of the American Association of Pharmaceutical Scientists, 2013
• University of Connecticut Teaching Fellow, 2008

Publications

T-H Fan, J-Q Li, B. Minatovicz, E. Soha, L. Sun, S Patel, B. Chaudhuri, R. Bogner, Phase-Field Modeling of Freeze Concentration of Protein Solutions (doi.org/10.3390/polym11010010), Polymers, 11(1):10 (2019).

Sharma, W.J. Kessler, R. Bogner, M. Thakur, M.J. Pikal, Applications of the Tunable Diode Laser Absorption Spectroscopy: In-Process Estimation of Primary Drying Heterogeneity and Product Temperature During Lyophilization (doi.org/10.1016/j.xphs.2018.07.031), Journal of Pharmaceutical Sciences, 108(1):416-430 (2019).

M.J. Pikal, P. Pande, R.H. Bogner, P. Sane, V. Mudhivarthi, P. Sharma, Impact of Natural Variations in Freeze-Drying Parameters on Product Temperature History: Application of Quasi Steady-State Heat and Mass Transfer and Simple Statistics (doi.org/10.1208/s12249-018-1155-4), AAPS PharmSciTech, 19(7):2828-2842 (2018).

S.S. Kulkarni, R. Suryanarayanan, J.V. Rinella, Jr., R. H. Bogner, Mechanisms By Which Crystalline Mannitol Improves the Reconstitution Time of High Concentration Lyophilized Protein Formulations (doi.org/10.1016/j.ejpb.2018.07.022), European Journal of Pharmaceutics and Biopharmaceutics, 131: 70-81 (2018).

Fang, K. Tanaka, V. Mudhivarthi, R.H. Bogner, M.J. Pikal, Effect of Controlled Ice Nucleation on Stability of Lactate Dehydrogenase during Freeze-Drying (doi.org/10.1016/j.xphs.2017.10.020), Journal of Pharmaceutical Sciences, 107(3):824-830 (2018).

M.S. Kleppe, R.J. Haskell, R.H. Bogner, Biorelevant Media Slows the Solution-Mediated Phase Transformation of Amorphous Spironolactone (doi.org/10.1016/j.xphs.2017.10.041), Journal of Pharmaceutical Sciences, 107(1): 426-435 (2018).

Sane, N. Varma, A. Ganguly, M Pikal, A. Alexeenko, R.H. Bogner, Spatial variation of pressure in the lyophilization product chamber part 2: experimental measurements and implications for scale-up and batch uniformity (DOI: 10.1208/s12249-016-0502-6), AAPS PharmSciTech, 18(2):369-380 (2017).

S.B. Murdande, M.J. Pikal, R.M. Shanker, R.H. Bogner. Solubility Advantage of Amorphous Pharmaceuticals: 1. A Thermodynamic Analysis, Journal of Pharmaceutical Sciences. 99(3): 1254-1264 (2010).

BS Bhatnagar, RH Bogner, MJ Pikal, Protein Stability During Freezing: Separation of Stresses and Mechanisms of Protein Stabilization, Pharmaceutical Development and Technology, 12: 505-523 (2007).

D. Bahl, R.H. Bogner, Amorphization of Indomethacin by Co-Grinding with Neusilin US2: Amorphization Kinetics, Physical Stability and Mechanism, Pharm. Res., 23:2317-2325 (2006).

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