Kerry M. Gilmore

Assistant Professor

Lawrence E. Posner and Amy E. Newburger Fellow

Department of Chemistry

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Education

• Research Group Leader: Max-Planck Institute of Colloids and Interfaces (2014-2020)
• Postdoctoral Fellow: Max-Planck Institute of Colloids and Interfaces (2012-2014)
• Ph.D. Organic Chemistry: Florida State University (2012)
• B.S. Biology/B.S. Chemistry: Roger Williams University (2006)

Research Interests

Our group’s research uses flow chemistry as a platform to provide reproducibility, efficiency, and access to controlled reaction conditions. We apply this approach to a broad range of applications within organic chemistry, including the development of new reactions (photochemical, thermal, bi-/tri-phasic, catalytic, etc.), mechanistic studies, multistep syntheses, and process development. These studies include aspects and applications of computational chemistry, chemical engineering, software engineering and automation, machine learning, as well as instrument design/development. Projects in the group have ranged from multistep API syntheses, singlet oxygen oxidations, prediction of stereoselectivity using machine learning, the development of automated platforms for single or multistep flow synthesis, as well as a range of other topics. Our goal is to continuously identify and address challenging gaps in the literature and to pursue project that do not have a clear path at the onset.

Publications

Artemisinin Inhibits NRas Palmitoylation by Targeting the Protein Acyltransferase ZDHHC6 Qui, N.; Abegg, D.; Guidi, M.; Gilmore, K.; Seeberger, P. H.; Adibekian, A. Cell Chem. Bio. 2022, 29, 1. read it here

Click, Zoom, Explore: Interactive 3D (i-3D) Figures in Standard Teaching Materials (PDFs) Chatterjee, S.; Moon, S.; Rowlands, A.; Chin, F.; Seeberger, P. H.; Merbouh, N.; Gilmore, K. J. Chem. Ed. 2021, 98, 3470-3475. read it here

In vitro Efficacy of Artemisia Extracts Against SARS-CoV-2 Nie, C.; Trimpert, J.; Moon, S.; Haag, R.; Gilmore, K.; Kaufer, B. B.; Seeberger, P. H. BioRxiv. 2021, DOI: 10.1101/2021.02.14.431122. read it here

Combining Radial and Continuous Flow Synthesis to Optimize and Scale-up the Production of Medicines Guidi, M.; Moon, S.; Anghileri, L.; Cambié, D.; Seeberger, P. H.; Gilmore, K. React. Chem. Eng. 2021, 6, 220-224. read it here

Predicting Glycosylation Stereoselectivity Using Machine Learning. Moon, S.; Chatterjee, S.; Seeberger, P. H.; Gilmore, K. Chem. Sci. 2021, DOI:10.1039/D0SC06222G (Edge Article). read it here

In Vitro Efficacy of Artemisinin-Based Treatments Against SARS-CoV-2 Gilmore, K.; Zhou, Y.; Ramirez, S.; Pham, L. V.; Fahnoe, U.; Feng, S.; Offersgaard, A.; Trimpert, J.; Bukh, J.; Osterrieder, K.; Gottwein, J.; Seeberger, P. H. BioRxiv 2020, DOI:10.1101/2020.10.05.326637. read it here

How to Approach Flow Chemistry (Tutorial Review) Guidi, M.; Seeberger, P. H.; Gilmore, K.  Chem. Soc. Rev. 2020, 49, 8910-8932. read it here

The Impact of Leaving Group Anomericity on the Structure of Glycosyl Cations of Protected Galactosides Greis, K.; Mucha, E.; Lettow, M.; Thomas, D. A.; Kirschbaum, C.; Moon, S.; Pardo-Vargas, A.; von Helden, G.; Meijer, G.; Gilmore, K.; Seeberger, P. H.; Pagel, K. ChemPhysChem 2020, 21, 1905. read it here

Remote Participation During Glycosylation Reactions of Galactose Building Blocks: Direct Evidence From Cryogenic Vibrational Spectroscopy. Marianski, M.; Mucha, E.; Greis, K.; Moon, S.; Pardo, A.; Kirschbaum, C.; Thomas, D. A.; Meijer, G.; Helden, G. v.; Gilmore, K.; Seeberger, P. H.; Pagel, K. Angew. Chem. Int. Ed. 2020, 59, 6166-6172. read it here

Automated Radial Synthesis of Small Molecules Chatterjee, S.; Guidi, M.; Seeberger, P. H.; Gilmore, K.  Nature 2020, 579, 379-384. read it here