Sangamesh G. Kumbar

Associate Professor

Department of Orthopedic Surgery

UConn Health

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Education

• Ph.D., Karnatak University
• M.Sc., Karnatak University
• B.Sc., Karnatak University

Research Focus

• Polymeric Biomaterials
• Tissue Engineering
• Drug Delivery
• Bone, cartilage, peripheral nerve and tendon tissue regeneration

Awards

• Research Fellowship, 2000-2002
• Obtained Prof. E S. Jayadevappa Memorial Gold Medal (for being 1st rank in MSc.)
• National Merit Scholarship, 1982-1994

Publications

Kumar, A., Zhang Y., Terracciano A., Zhao, X., Su, T-L., Kalyon, D.M., Katebifar, S., Kumbar, S.G., Yu, X. Load-bearing biodegradable polycaprolactone-poly (lactic-co-glycolic acid)-beta tri-calcium phosphate scaffolds for bone tissue regeneration. Polym. Adv. Technol. 2019;1–9, doi.org/10.1002/pat.4551. Impact Factor- 2.137.

Chang, JH., Chen, P.J., Arul, M.R., Dutra, E.H., Nanda, R., Kumbar, SG., Yadav, S. Injectable RANKL sustained release formulations to accelerate orthodontic tooth movement. European Journal of Orthodontics, 2019, 1–9 doi:10.1093/ejo/cjz027 1508. ( Note- SGK and SY both corresponding authors). Impact Factor- 1.841.

Ramos, D.M., Abdulmalik, S., Arul, M., Rudraiah, S., Laurencin, C.T., Mazzocca, C.T., Kumbar, S.G., Insulin Immobilized PCL-Cellulose Acetate Micro-Nano Structured Fibrous Scaffolds for Tendon Tissue Engineering. Polym. Adv. Technol. 2019;1–11, doi.org/10.1002/pat.4553. Impact Factor- 2.13.

Manoukian, O.S., Arul, M., Rudraiah, S., Kalajzic, I., Kumbar, S.G., Aligned Microchannel Polymer-Nanotube Composites for Peripheral Nerve Regeneration: Small Drug Molecule Delivery. J. Control. Release. 296 (2019) 54–67. doi.org/10.1016/j.jconrel.2019.01.013. Impact Factor- 7.877.

Manoukian, O.S, Baker, J.T., Rudraiah, S., Arul, M.R., Vella, A.T., Domb, A.J., Kumbar, S.G., Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration. J Control Release. 2019;317:78-95. doi: 10.1016/j.jconrel.2019.11.021. Impact Factor- 7.877.

Suhail, S., Sardashti, N., Jaiswal, D., Rudraiah, S., Misra, M., Kumbar S.G., “Engineered Skin Tissue Equivalents for Product Evaluation and Therapeutic Applications.” Biotechnol J. 2019 Apr 12:e1900022. doi: 10.1002/biot.201900022. Impact Factor-3.446.

Abdulmalik S, Katebifar S, Nip J, Yousman L, Szarejko P, Baker J, Rudraiah R, Kumbar S.G. “Nanofibers for Soft-Tissue engineering” in Artificial Protein and Peptide Nanofibers. Editors G. Wei and S. G. Kumbar. Elsevier Academic Press 2019 (Accepted in Press).

Manoukian, OS, Sardashti, N., Stedman, T., Gailiunas, K., Ojha, A., Penalosa, A., Mancuso, C., Hobert, M., Kumbar S.G., “Biomaterials for Tissue Engineering and Regenerative Medicine” in “the Encyclopedia of Biomedical Engineering” Editors Hargrove et al. Elsevier Academic Press. 2019; Vol 1, 462-482.

Ramos, D.M., Dhandapani, R., Subramanian, A., Sethuraman, S., Kumbar, SG., Clinical complications of biodegradable screws for ligament injuries. Materials Science and Engineering: C, 2020, 109,1104232 (Note- SGK and SS both corresponding authors). Impact Factor- 4.959.

Aravamudhan, A., Ramos, D.M., Jenkins, N. R., Dyment, N.A., Sanders, M.M., Rowe, D., and Kumbar, S.G.* Collagen nanofibril self-assembly on a natural polymeric material for the osteoinduction of stem cells in vitro and biocompatibility in vivo, RSC Advances, 2016, 6, 80851-80866.

Lee, P., Manoukian, O.S., Zhou, G., Wang, Y., Chang, W., Yu, X and Kumbar, S.G.* Osteochondral Scaffold Combined with Aligned Nanofibrous Scaffolds for Cartilage Regeneration. RSC Advances, 2016, 6, 72246-72255.

Lee, P., Tran, K., Zhou, G., Bedi, A., Shelke, N.B., Yu, X* and Kumbar, S.G.* Guided Differentiation of Bone Marrow Stromal Cells on Co-Cultured Cartilage and Bone Scaffolds. Soft Matter, 2015, 11, 7648-7655.

Lee, P., Tran, K., Chang, W., Fang, S., Shelke, N.B., Yu, X*, and Kumbar, S.G.* Bioactive Polymeric Scaffolds for Osteochondral Tissue Engineering: In vitro Evaluation of the Effect of Culture Media on Bone Marrow Stromal Cells. Polym. Adv. Tech., 2015, 26, 1476–1485.

Shelke, N.B., Lee, P., Anderson, M., Mistry, N., Nagarale, R.K, Ma, X.M., Yu, X. and Kumbar, S.G.* Nanofiber-Hydrogel Based Composite Scaffolds for Nerve Regeneration. Polym. Adv. Tech., 2015, 27, 42–51.

Guadalupe E., Ramos D.M., Shelke N.B., James R., Gibney C., and Kumbar, S.G.* Bioactive Polymeric Nanofiber Dressings for Wound Healing. J. Appl. Polym. Sci. 2015, 132, 41879.

Jaiswal D., James, R., Shelke N.B., Harmon M.D., Brown J. L., Hussain F., and Kumbar, S.G.* Gelatin Nanofiber Matrices Derived from Schiff Base Derivative for Tissue Engineering Applications. J. Biomed. Nanotechnol., 2015, 11 (11) 2067-2080.

James, R., Nagarale, R.K., Sachan, V., Badalucco, C., Bhattacharya P., and Kumbar, S.G.* Synthesis and Characterization of Electrically Conducting Polymers for Regenerative Engineering Applications: Sulfonated Ionic Membranes. Polym. Adv. Tech., 2014, 25, 1439–1445.

Lee, P., Tran, K., Chang, W., Shelke, N.B., Kumbar, S.G.* and Yu, X*. Influence of Chondroitin Sulfate and Hyaluronic Acid Presence in Nanofibers and Its Alignment on the Bone Marrow Stromal Cells: Cartilage Regeneration. J. Biomed. Nanotechnology, 2014, 10 (8), 1469-1479.

Nada, A.A., James, R., Shelke, N.B., Harmon, M.D., Awad, H. M., Nagarale, R. K., Kumbar, S.G.* A Smart Methodology to Fabricate Electrospun Chitosan Nanofiber Matrices for Regenerative Engineering Applications. Polym. Adv. Tech., 2014, 25 (5), 507-515.