Tannin A. Schmidt

Associate Professor

Department of Biomedical Engineering

UConn Health

Education

  • Postdoc, Rush University Medical Center, Chicago; Rheumatology & Biochemistry (2008)
  • Ph.D., University of California, San Diego, Bioengineering (2006)
  • M.S., University of California, San Diego, Bioengineering (2002)
  • B.A. Sc., University of Toronto, Engineering Science (2000)

Research Topics

  • Elucidate the molecular basis of articular cartilage boundary lubrication through the study of PRG4 interactions with itself, with hyaluronan and other synovial fluid constituents, and the articular cartilage surface.
  • Examine the composition and interaction of PRG4+hyaluronan in osteoarthritic synovial fluid, and their effects on articular cartilage boundary lubrication.
  • Assess PRG4’s potential as a boundary lubricant of knee implant biomaterials.
  • Characterize and develop novel PRG4, +/-hyaluronan, containing contact lens biomaterials with enhanced boundary lubricating properties.
  • Examine PRG4’s potential as an anti-inflammatory therapeutic for the treatment of inflammatory arthritis, as well as preventing post-surgical pericardial adhesions and cancer metastasis.

Publications

Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation.

Menon, Nikhil G; Goyal, Ruchi; Lema, Carolina; Woods, Paige S; Tanguay, Adam P; Morin, Alyssa A; Das, Nabangshu; Jay, Gregory D; Krawetz, Roman J; Dufour, Antoine; Shapiro, Linda H; Redfern, Rachel L; Ghosh, Mallika; Schmidt, Tannin A Experimental eye research 2021 Jul;208108628

The role of synovial fluid constituents in the lubrication of collagen-glycosaminoglycan scaffolds for cartilage repair.

Matheson, Austyn R; Sheehy, Eamon J; Jay, Gregory D; Scott, W Michael; O’Brien, Fergal J; Schmidt, Tannin A Journal of the mechanical behavior of biomedical materials 2021 Jun;118104445

Proteoglycan 4 reduces friction more than other synovial fluid components for both cartilage-cartilage and cartilage-metal articulation.

Damen, A H A; van Donkelaar, C C; Cardinaels, R M; Brandt, J-M; Schmidt, T A; Ito, K Osteoarthritis and cartilage 2021 Feb;

Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications: A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin).

Korogiannaki, Myrto; Samsom, Michael; Matheson, Austyn; Soliman, Karim; Schmidt, Tannin A; Sheardown, Heather Langmuir : the ACS journal of surfaces and colloids 2021 Jan;37(3):1062-1072

Effects of acidosis on the structure, composition, and function of adult murine femurs.

Peterson, Anna K; Moody, Mikayla; Nakashima, Iris; Abraham, Ron; Schmidt, Tannin A; Rowe, David; Deymier, Alix Acta biomaterialia 2020 Nov;

Proteoglycan-4 is correlated with longer survival in HCC patients and enhances sorafenib and regorafenib effectiveness via CD44 in vitro.

Dituri, Francesco; Scialpi, Rosanna; Schmidt, Tannin A; Frusciante, Martina; Mancarella, Serena; Lupo, Luigi Giovanni; Villa, Erica; Giannelli, Gianluigi Cell death & disease 2020 Nov;11(11):984

Lubricating lipids in hydrogels.

Schmidt, Tannin A Science (New York, N.Y.) 2020 Oct;370(6514):288-289

Microneedle arrays for the treatment of chronic wounds.

Barnum, Lindsay; Samandari, Mohamadmahdi; Schmidt, Tannin A; Tamayol, Ali Expert opinion on drug delivery 2020 Oct;1-14

Automated Indentation Demonstrates Structural Stiffness of Femoral Articular Cartilage and Temporomandibular Joint Mandibular Condylar Cartilage Is Altered in FgF2KO Mice.

Woods, Paige S; Morin, Alyssa A; Chen, Po-Jung; Mahonski, Sarah; Xiao, Liping; Hurley, Marja; Yadav, Sumit; Schmidt, Tannin A Cartilage 2020 Oct;1947603520962565

Proteoglycan 4 reduces neuroinflammation and protects the blood-brain barrier after traumatic brain injury.

Bennett, Marissa; Chin, Andrea; Lee, Hyung Jin; Morales Cestero, Emma; Strazielle, Nathalie; Ghersi-Egea, Jean-François; Threlkeld, Steven; Schmidt, Tannin; Richendrfer, Holly; Szmydynger-Chodobska, Joanna; Jay, Gregory; Chodobski, Adam Journal of neurotrauma 2020 Sep;
Tannin Schmidt
Contact Information
Emailtannin.schmidt@uconn.edu
Phone860-679-8361
Mailing Address263 Farmington Avenue, Farmington, CT 06030
Office LocationUConn Health
CampusUConn Health
Linkhttps://facultydirectory.uchc.edu/profile?profileId=Schmidt-Tannin