A research study recently published in the Journal of the American Chemical Society (JACS) presents a breakthrough in the design of synthetic copolypeptides which mimic the mechanical properties of spider silk.

The study, entitled Synthesis and In Situ Thermal Induction of β-Sheet Nanocrystals in Spider Silk-Inspired Copolypeptides, was conducted in the research lab of IMS resident faculty member and Professor of Chemistry, Dr. Yao Lin, in collaboration with Dr. Jianjun Cheng, Professor of Materials Science and Engineering at the University of Illinois Urbana Champaign (UIUC). Graduate students Tianjian Yang and Jianan Mao (UConn) and Tianrui Xue (UIUC) provided essential contributions to the study.

Leveraging advanced helix-accelerated, ring-opening polymerization techniques, the research team synthesized multiblock copolypeptides, which undergo a transformation into β-sheet nanocrystals upon heating, achieving robust materials with excellent mechanical integrity, tunability, and processability without the need for solvents.

The study also expands upon traditional poly-alanine-based constructs found in natural spider silk by introducing novel β-sheet-forming amino acids, offering new ways to tailor these materials for specific functional applications. This approach is expected to pave the way for next-generation biopolymer and high-performance fiber materials whose properties will include increases in tensile strength, extensibility, processability, and versatility similar to natural spider silk.

Professor Lin’s group studies bio-inspired macromolecules and materials using the techniques of polymer synthesis, macromolecular characterization, physical chemistry, molecular biology and biochemistry as tools.

Visit the JACS site to read the research.

---