IMS Students

Institute of Materials Science Alumni Feature: Ayana Ghosh

by Paige Bjerke
IMS Written Communications Assistant

Ayana Ghosh ('20)
Ayana Ghosh, Ph.D. (’20)

Ayana Ghosh received her Ph.D. in Materials Science and Engineering from the University of Connecticut in 2020. Afterwards, she joined the prestigious Oak Ridge National Laboratory (ORNL) of the U.S. Department of Energy as a postdoctoral research associate. In 2023, she moved into a full-time position as a staff scientist. In this role, Ghosh has excelled in her research, having won copious awards, spoken at conferences around the world, and gotten published in multiple peer-reviewed journals.

IMS News reached out to Ghosh with five questions about her current position, her many achievements, and her plans for the future.

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You have clearly set yourself apart at Oak Ridge, having won various awards in just a few years. What skills do you feel propelled you to such impressive success, and what support systems, either within your research team or elsewhere, have helped you the most, and how?

Success in research is often non-linear. It involves many days when things don’t work out or…challenges I don’t fully understand. However, I’ve learned that the key to progress is being able to formulate a clear and meaningful scientific problem and then break it down into manageable parts. This helps me maintain a steady pace toward achieving the final goal. I believe that embracing new ideas and constantly learning—despite the challenges—are key drivers of growth and innovation. Above all, consistency, determination, and resilience have been essential to my success. Giving my best effort, even in the face of setbacks, has played a key role in driving my progress.

The support of my mentors during my postdoctoral work (September 2020 to February 2023), ongoing encouragement from my group leader at ORNL, along with the valuable feedback, collaboration, and shared knowledge from my colleagues and collaborators at ORNL and across the globe, have been instrumental in navigating challenges and advancing my work. I continue to stay in touch with my graduate school advisors and faculty, whose guidance remains invaluable in shaping my research journey.

I would like to express my deep gratitude to my mother, whose unwavering support has been a constant source of strength throughout my journey. After the sudden passing of my father during the pandemic in 2021, I faced the challenge of navigating both personal loss and the demands of my academic work. Her courage has been an anchor, helping me to persevere through difficult times and stay focused on my goals.

Working for ORNL, part of the U.S. Department of Energy, how do you grapple with the importance and scale of your work, which undoubtedly shapes government policy and affects the wellbeing of America and the world at large? 

The motivation behind my work has always been the desire to address real-world problems, with the hope to contribute to technological advancements and innovations that improve people’s lives. Working at a U.S. Department of Energy lab, I recognize that my work certainly carries significant weight, particularly knowing that it can influence government policy and ultimately affect the wellbeing of individuals not just in America, but globally. I try to focus on the positive change I hope to drive rather than feel overwhelmed by the scale of it.

I’m also constantly supported by a network of colleagues, mentors, and collaborators who keep me grounded. One of the coolest things about being part of a national lab is the opportunity to casually interact with brilliant minds from various fields. Imagine this: taking an afternoon walk around the building where you might bump into a computer scientist, mathematician, or physicist, and get to chat about the problems you’re working on, gaining fresh perspectives and ideas. It’s amazing how these conversations can spark new ways of thinking, often leading to creative solutions. I also remind myself that progress is often incremental—every small step adds up to a bigger picture. Balancing the scale of my work comes from staying connected to the people and principles that matter most and keeping my focus on the long-term goals.

In 2021, you stated that you “hope to better understand the nuances of experimental research as combined with the particulars of theoretical and simulated data.” Have you been able to gain that understanding at this point in your career? If so, to what extent and how does that understanding inform your current work? If not, what do you feel are the barriers to achieving that understanding?

This is still an ongoing process. Much of my postdoctoral and current work has been dedicated to understanding the nuances between experimental research and theoretical/simulated data. We have made significant strides, particularly in autonomous microscopy, developing machine learning workflows to enhance our understanding of experimental data and integrate it with theoretical simulations.

However, challenges remain, particularly around the disparities between time and length scales. Real-time experiments often don’t align perfectly with theoretical approximations. These gaps require more adaptive approaches. I believe addressing these grand challenges will be crucial not only for my work, but also for improving the synergy between experimental and computational methods. This synergy is essential for unlocking new insights and driving innovation in the world of materials and beyond.

Your Ph.D. thesis was based heavily on machine learning, which you still employ frequently in your work at ORNL. What should current students in the field of materials science know about machine learning and AI, and how would that knowledge benefit them? 

For graduate students in materials science, getting comfortable with the basics of ML and AI is crucial. Start by understanding the algorithms, their implementation, and how to apply them to real-world problems. The key is knowing when and how to use these tools, based on solid domain expertise. It’s not just about using fancy algorithms or architectures, it’s about identifying the problems in materials science that can benefit from them. Beyond just applications, there’s also a big opportunity for students to get involved in method development to push the boundaries of what’s possible.

On a broader note, AI is shaking up every field – it’s changing how we teach and learn, too. With AI-assisted teaching, personalized learning, and a wealth of accessible tools, I think we’re on the brink of a classroom revolution. It’s an exciting time. I imagine embracing these changes will only make us all better researchers and learners. So, for students, one piece of advice, don’t just sit back – dive in and start experimenting (in the lab and on the computer)!

With so much recognition already, and new projects going on constantly, what are your goals or specific things you want to achieve over the next 10 years?

Looking ahead, I am committed to pushing the boundaries of my field by advancing technological solutions that tackle some of the world’s most pressing challenges in energy, AI, and quantum technologies. I am particularly excited about the potential of deepening our understanding of the foundational principles of materials physics and bridging theory with real-world experiments. This integration will be crucial in developing practical, scalable solutions that address the evolving challenges in both society and technology.

With an eye on what’s next, my goal is to take on more leadership roles, collaborating with a diverse range of experts across disciplines to drive innovation and create meaningful change. Equally important is my commitment to mentoring young researchers and contributing to the development of the next generation of scientists. At the same time, I recognize the importance of balancing career advancement with maintaining personal well-being, ensuring both professional growth and personal fulfillment.

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IMS News thanks Dr. Ghosh for taking the time to answer our questions and providing such potent insight into her work. We wish her all the best as she continues her exciting and innovative career journey.

 

Qiaoling Fan from Hohman Group Published in JACS

Qiaoling Fan
Ph.D. student, Qiaoling Fan, is a member of Professor J. Nathan Hohman’s group

by Linda Costa
IMS Written Communications Assistant

Qiaoling Fan, a member of IMS resident faculty member and Professor of Chemistry, Nathan Hohman’s research group, has been published in JACS (the Journal of the American Chemical Society). Fan is currently a third-year graduate student in inorganic chemistry here at the University of Connecticut.

JACS is a weekly scientific journal published by the American Chemical Society. Published research undergoes a rigorous peer-review process.

Fan’s research, entitled Nucleophilic Displacement Reactions of Silver-Based Metal-Organic Chalcogenolates (MOChas), provides a new synthetic route for the preparation of more elaborate MOChas and heterostructures. Her research has also enabled the preparation of unreachable oligophenyl MOChas which lead to an applicable platform to create complex 2D inorganic phases.

The Hohman Research Group currently includes eight graduate students and one undergraduate student. The group’s research focuses on the design and synthesis of nanomaterials and nanointerfaces for applications, understanding origins of how different structure leads to function in complex materials, and solving synthetic problems. Their work has earned a Department of Energy (DoE) grant to help further their research.

“Working with Dr. Hohman’s group has been fulfilling, both intellectually and creatively,” Fan says. “Collaborating with talented peers in Dr. Hohman’s lab has been a constant learning experience, fostering interdisciplinary thinking and dynamic idea exchanges. What excites me most about our research is its potential real-world impact, particularly in display technology.

Fan earned her Bachelor of Science degree from Sichuan Normal University in Chengdu, China followed by a master’s in chemistry at East China Normal University in Shanghai, China. She also spent time as a high school chemistry teacher in China.

“Teaching at this level was a unique experience that helped me grow both professionally and personally,” fan recalled. “One of the most rewarding aspects of teaching was watching my students grow and develop a curiosity for chemistry. What I hoped my students would take away from my teaching was not just a set of chemical facts but an appreciation for the scientific process and the world around them.”

Three Students from Duduta Group Awarded NASA CTSGC Fellowships

Duduta group members surround logo of NASA CT
Dominic Flores (top), Sahib Sandhu (bottom left) and Alexander White (bottom right) from the Duduta Group

NASA Connecticut Space Grant Consortium (CTSGC) is a federally mandated grant, internship, and scholarship program funded as a part of NASA Education. Formed in 1991 by Trinity College, University of Connecticut, University of New Haven, and University of Hartford, NASA CTSGC encourages broader participation in NASA research programs.
Three graduate students from Prof. Mihai “Mishu” Duduta’s group (Dominic Flores, Sahib Sandhu and Alexander White) have won NASA Connecticut Space Consortium Graduate Fellowships of $10,000 each to support research at the interface of soft and space robotics.

Dominic Flores was awarded $10,000 for his research proposal entitled Dielectric Elastomer Actuator Grippers with Sensing Capabilities for Space Applications.

Sahib Sandhu was awarded $10,000 for his research proposal entitled Space ready deployable composites based on compliant capacitors.

Alexander White was awarded $10,000 for his research proposal entitled Spacecraft Landing System using Soft Tunable Tensegrity Structures.

IMS congratulates Dominic, Sahib, and Alexander!

EIRC Lab Mates Like Family

Kerry Lynn Davis-AmendolaKerry Lynn Davis-Amendola beautifully shares her experience as a current Ph.D. student in the Electrical Insulation Research Center (EIRC) paying special attention to the importance of her lab mates and the camaraderie that awaited her when she joined the lab.  The inspiring article, The Best Part of a PhD that No One Is Talking About, appears in the “Young Professionals” section of the July/August 2023 edition of the journal IEEE.

IMS Industrial Affiliates Program Hosts 2023 Annual Meeting

2023 Annual Meeting - Morning Session
The morning session was held in the Science 1 Active Learning Classroom.

On May 25, 2023, the Institute of Materials Science (IMS) Industrial Affiliates Program (IAP) held its first in-person annual meeting since the onset of the COVID-19 pandemic in 2020.

The meeting began with a welcome message by Dr. Hatice Bodugoz-Senturk, Associate Director of the IMS Industrial Affiliates Program, followed by remarks by Dr. Steven L. Suib, Director of IMS, and Dr. Paul Nahass, Director of the IMS Industrial Affiliates Program. Dr. Bryan Huey, Department Head of Materials Science and Engineering (MSE) gave an overview of the MSE department and its achievements; and Dr. Kelly Burke, Director of the IMS Polymer Program, discussed the latest developments in polymer science.

Dr. George Matheou presents
Dr. Georgios Matheou presents his research at the morning session of the 2003 Annual Meeting

The morning session featured three presentations by IMS faculty members from different departments. Dr. James “Nate” Hohman, Assistant Professor of Chemistry, talked about his research on experimental foundations for next-generation materials and interfaces, and how he uses big science, big data, and big AI to discover new materials for various applications. Dr. Georgios Matheou, Assistant Professor of Mechanical Engineering, presented his work on predictive modeling and simulation of multi-physics flows, and how he collaborates with industry partners in renewable energy, aerospace, and health care sectors. Dr. Vahid Morovati, Assistant Professor of Civil and Environmental Engineering, explained his theoretical framework to model the long-term mechanical behavior of elastomeric materials considering damage accumulation and degradation.

The luncheon session featured a keynote address by Dr. Anne D’Alleva, Provost and Executive Vice President for Academic Affairs, who shared her vision and goals for UConn’s academic excellence and innovation. She also highlighted the importance and impact of materials science and engineering in addressing the global challenges and opportunities in the 21st century. The luncheon concluded with closing remarks by Dr. Paul Nahass.

2023 Annual Meeting Luncheon 2
IMS Director Dr. Steven L. Suib addresses industry partners, faculty, and students at the 2023 Annual Meeting Luncheon

The meeting was attended by more than 100 participants from industry affiliates and external partners along with IMS faculty, students, and alumni. The meeting also showcased the annual Joint Poster Session by IMS Polymer Program and Materials Science and Engineering (MSE) students, demonstrating their projects and achievements in materials science and engineering.  Industry partners were also given tours of core laboratories in the Science 1 building, the new home to IMS.

The IMS Industrial Affiliates Program provides materials characterization services to its industry partners. The program also facilitates collaborations between IMS faculty and students and industry partners on research projects of mutual interest.

The Institute of Materials Science is an interdisciplinary research institution that supports over 100 faculty members from 15 departments across UConn’s schools and colleges. The institute offers advanced degrees in polymer science and materials science, as well as state-of-the-art research facilities for its students and faculty to conduct research that is changing the future of materials science.

Polymer Program Announces 2021-2022 Awards

The IMS Polymer Program Awards committee has selected two awardees for the 2021 – 2022 academic year.

Chung Hao Polymer Program Award
Chung Hao (center), winner of the Samuel J. Huang Graduate Student Research Award, with Polymer Program Director Kelly Burke (left) and advisor, Dr. Mu-Ping Nieh.

Chung-Hao Liu received the Samuel J. Huang Graduate Student Research Award.  This award recognizes a graduate student for outstanding research in the field of polymer science and engineering.  Chung-Hao completed is fourth year as a polymer PhD candidate under the guidance of Prof. Mu-Ping Nieh. He has been diligent in conducting advanced nanoscience research including materials characterization and designing polymer nanostructures. His efforts have resulted in two published journal articles, one currently in review, and contributions to many more. Chung-Hao has also made many collaborating efforts with other research groups and mentored undergraduate engineering students. Outside the lab, Chung-Hao has been an Society of Polymer Engineers, Storrs Chapter, committee member for 3 years, serving as both Vice President and President. His positive attitude and strong work ethics have made contributions to Prof. Nieh’s lab and the IMS research community.

 

Probodha Abeykoon Receives 2022 Polymer Program Award
Probodha Abeykoon (center), winner of the Stephanie H. Shaw Fellowship Scholar Award, with Polymer Program Director Kelly Burke and advisor, Dr. Douglas Adamson.

Probodha Abeykoon has been recognized as this year’s Stephanie H. Shaw Fellowship Scholar. This award is designated for a female student showing academic achievement and contributions outside of research.  Probodha has served as the leader of the Adamson Research Lab and has taken it upon herself to be the resident expert in several analytical techniques, such as four-point probe and thermal conductivity. She has two published papers and a third manuscript recently submitted. She has also presented her work at several ACS National Meetings. During the past 4 years Probodha has grown in into an excellent scientist and group leader.

The polymer program congratulates this year’s awardees with their tremendous efforts in both research and leadership in the IMS community.

Rapid Virus Test Being Studied in Zhang Group will Differentiate SARS-CoV-2 from Other Respiratory Viruses

Yi Zhang Group
(from left to right) Guangfu Wu, Huijie Li, and Zhengyan Weng, advised by Professor Yi Zhang, are checking an array of graphene field-effect transistors.

In recent years, from H1N1 and now to SARS-CoV-2, global pandemics caused by highly contagious viral species have been threatening human life and putting tremendous pressure on healthcare services as well as the economy. Rapid testing and timely interventions for asymptomatic or mild infections caused by SARS-CoV-2, for example, would enable efficient quarantine of infected patients, thus significantly reducing the spread rate of the virus. Importantly, SARS-CoV-2 is expected to continue in the future fall/winter seasons, when it will coincide with the seasonal outbreak of other infectious respiratory diseases, including those caused by influenza virus and respiratory syncytial virus, which have similar signs and symptoms in the early stages. Considering the overlap in the seasonal peaks, symptoms, and underlying risk factors of these illnesses, having a rapid test to detect and differentiate SARS-CoV-2 from other infectious respiratory viruses will be clinically important.

In response to this clinical need, the Institute of Materials Science and Biomedical Engineering Assistant Professor Yi Zhang led the development of the most sensitive amplification-free SARS-CoV-2 diagnostic platform, the CRISPR Cas13a graphene field-effect transistor. This study, entitled “Amplification-Free Detection of SARS-CoV-2 and Respiratory Syncytial Virus Using CRISPR Cas13a and Graphene Field-Effect Transistors,” was published online on May 12, 2022, in the journal Angewandte Chemie International Edition.

“The key features of viral diagnostics are rapidness and sensitivity,” said Zhang. According to Zhang, most virus detection techniques, including the gold-standard RT-PCR, relies on viral sequence amplification, which can dramatically complicate the detection process and increase the risk of cross-contamination, therefore subject to elevated false-positive rates. However, current amplification-free methods are still limited by compromised sensitivity. “Our work revolutionized the field of amplification-free nucleic acid diagnostics by introducing a biosensing platform with sensitivity comparable with RT-PCR,” he said.

Yi Zhang
Dr. Yi Zhang

Derived from adaptive immunity in prokaryotes, Nobel-winning clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) technology leverages nucleic acid base pair complementarity between a guide RNA and targeted nucleic acid sequence and affords high target specificity capable of discriminating single mismatches. Recently, several CRISPR/Cas systems, including Cas13a, were found to perform cleavage of nonspecific bystander nucleic acid probes triggered by target detection, known as “collateral cleavage.” Such collateral cleavage demonstrates a multi-turnover behavior, turning a single target recognition event into multiple probe cleavage events, and therefore leads to signal amplification.

“The idea of our biosensor design originates from exploiting the signal amplification by translating CRISPR technology onto an ultrasensitive detection platform,” said Huijie Li, a Ph.D. student in Zhang’s lab; she is also the leading first author of the study. Graphene, as a two-dimensional material, exhibits extraordinary charge carrier mobility and thus high electrical conductivity. Thanks to its atomic thickness, graphene, when constructed into biosensors as a sensing material, is highly sensitive to the interaction with biological analytes. In this study, by immobilizing probes on graphene-based field-effect transistors and allowing Cas13a collateral cleavage of these probes activated by target detection, SARS-CoV-2 down to 1 aM level in both spiked and clinical samples, was successfully detected within a 30 min detection time.

Simply by changing the guide RNA design, CRISPR Cas13a graphene field-effect transistor platform was reconfigured to target respiratory syncytial virus with the same attomolar sensitivity. “As the COVID-19 pandemic wanes, our virus diagnostic tool can be easily adapted to combat the future outbreak of unknown viral species,” Guangfu Wu, a Postdoc in Zhang’s lab; he is the co-first author of this work, said.

This study marks a significant milestone towards our goal of developing an integrated point-of-care biosensing platform for viral diagnostics. “We are aiming to offer patients a fast, ultrasensitive all-in-one tool that can streamline sample treatment and analysis and deliver results without any specialized training,” said Zhengyan Weng, a Ph.D. student in Zhang’s lab; he is also the co-first author of this study.

 

This research is supported by the University of Connecticut start-up and the National Science Foundation under the award number CBET-2103025. The collaborators of this work include Dr. Xue Gao at Rice University (co-corresponding author), Drs. Kevin D. Dieckhaus and Lori Avery at UConn Health, and Dr. Yupeng Chen in the Department of Biomedical Engineering at UConn.